The Holy Spirit is the one you don't want to mess with

Jesus said mess with me, kick me, spit on me, mock me, kill me; but don't mess with the one who is coming after me. After Him you have nothing.

People, if they think about it at all, think of the Holy Spirit (the third Person of the Godhead, or Trinity) as being innocuous, and not threatening. Yet it's the Holy Spirit among the Persons of the Trinity that you don't want to mess with.

The Holy Spirit is quick-triggered if you deny His work, for instance. Never tell somebody they're not a Christian, for instance, because you can't know what is going on between them and God. You can confront and engage someone on doctrine or behavior, just don't make pronouncements about whether they are Christian if they self-identify as such.

In many ways the Holy Spirit is the most detached of the three Persons of the Godhead in his role in the economy of redemption. He is applying what the Son has accomplished to those the Father has chosen. Thus He seems to perhaps have less patience for human arrogance and intransigence.

He is, though, willingly grieved by man when He takes up residence in man, but the impatience with man can have effect in areas of sanctification.